PISD and hepatocellular carcinoma: The succinylation of LACTB suppresses its own proteolytic activity, leading to an increase in its substrates, such as mitochondrial enzyme phosphatidylserine decarboxylase (PISD), lysophosphatidylethanolamines (LPEs), and phosphatidylethanolamines (PEs) in mitochondria, thereby increasing mitochondrial membrane potential and mitochondrial respiration, enhancing mitochondrial function, and promoting the progression of HCC [81].