Silencing of host factors such as Hsp68 and the antimicrobial peptide Microplusin appeared to restrict virus production early on (Fig. 5c), while targeting the N interactor DHX9, restricted SFTSV virus production at both 3 and 6 d.p.i., suggesting a critical role for this RNA helicase A during viral infection (Fig. 5i). Here, DHX9 is linked to viral infectious disease.