Similarly, higher proliferation rates were observed in the small-intestinal tumor organoids derived from cis-Apc+/−Cdx1+/− mice (Fig. 3B) and in colonic tumor organoids derived from cis-Apc+/−Cdx1+/− and Cdx2+/−-cis-Apc+/−Cdx1+/− mice than in those derived from Apc+/− mice (Fig. 3C, D). This evidence concerns the gene APC and neoplasm.