LGR5 and neoplasm: In colonic tumor organoids derived from cis-Apc+/−Cdx1+/− and Cdx2+/−-cis-Apc+/−Cdx1+/− mice, the expression of Cdx1 and Cdx2 was lower than that in Apc+/− tumor organoids, whereas that of Lgr5 was higher (Fig. 3A).