Interestingly, we also noted that while the cell cycle marker pRb is well correlated with the ERK-related markers c-Myc and Fra-1 in MCF10A (Supplementary Fig. S4c), pRb is correlated strongly with c-Myc but poorly with Fra-1 across all three cancer cell lines (Supplementary Fig. S8d). This evidence concerns the gene FOSL1 and cancer.