HSPA8 and cardiac hypertrophy: HSC70 was reported to be closely associated with the development of cardiac hypertrophy [54, 55]; however, it is primarily involved in chaperone-mediated autophagy and lysosomal degradation, not ubiquitin-mediated degradation [56], and its binding strength with Asb10 is 10-fold weaker than that of HSP70 with Asb10.