All these results were recapitulated by the silencing of the WT1 and FOXA1 as well as by using the AR inhibitor ENZ, which further confirms that the functional impact of the miR-1/-26a-1/-487b signature on GBM response to TMZ is mediated by the WT1/FOXA1/AR axis. This evidence concerns the gene FOXA1 and glioblastoma.