ABCB1 and cancer: Beyondtheir metallophore properties, lusichelins, particularlylusichelin B (2), exhibit promising anticancer potential.Lusichelin B (2) demonstrated potent cytotoxicity againstboth monolayer cultures and tumor spheroids of human colon carcinomaHCT 116 cells, and it effectively overcame cancer MDR by modulatingthe efflux activity of the ABCB1 transmembrane pump.