UOX and gout: Nevertheless, the application of a single specific strain or bacterial metabolite for gout intervention has rarely been explored and the underlying regulatory mechanism remains elusive.<h4>Objectives</h4>To ascertain the potential role and the molecular mechanism of Clostridium butyricum and butyrate in the management of gouty arthritis.<h4>Methods</h4>A Uox-KO mouse model of gouty arthritis was developed and the composition of the gut microbiota was analyzed.