PDGFRB and kidney failure: The PDGF system is actively involved in multiple kinds of organ fibrosis.36 PDGFRβ is a molecular target for lung fibrosis because anti-PDGFRβ, but not anti-PDGFRɑ, antibodies inhibit bleomycin-induced pulmonary fibrosis in mice.37 Renal mesenchymal PDGFRb activation induced kidney failure and fibrosis in mice.38 These findings provide a strong rationale for studying PDGFRβ as a target in intestinal fibrosis.