In addition, the levels of GSDMD-mediated pyroptosis were markedly lower in the livers of Glut9HKO mice subjected to either WD or WD + CCl4 treatment than in those of control mice (Fig. 4C) as were the levels of the secreted forms of IL-1β and IL-18 (Fig. 4D). The gene discussed is IL1B; the disease is Wilson disease.