Moreover, liver-specific knockout of Glut9 significantly alleviated the increase in hepatic UA levels and alleviated the increase in UA-induced NLRP3/Caspase-1/GSDMD-mediated hepatocyte pyroptosis in primary hepatocytes and NASH mice, ultimately leading to a reduction in pyroptosis in the NASH model. Here, GSDMD is linked to metabolic dysfunction-associated steatohepatitis.