NR4A1 and breast cancer: Characterized by increased fibrillar collagen deposition, less adipose tissue, and greater proportions of stroma, high mammographic density (MD) is associated with a four to six times greater BC risk [15–17] and with more aggressive BC, including larger tumors, increased spread to nearby lymph nodes, and cancers that are high grade and stage, rapidly growing, and hormone-receptor negative [6,17–20].