To corroborate the RCC’s CD40L-CD40–mediated susceptibility to noncanonical cytotoxicity in a different patient cohort and to confirm the pivotal role of CD8+ T cell–derived CD40L, we used data from the checkmate-009, checkmate-010, and checkmate-025 studies, which were compiled in the study of Braun et al. (34). The gene discussed is CD40LG; the disease is renal cell carcinoma.