IL1B and early-onset autosomal dominant Alzheimer disease: IL-1β is of particular interest as numerous studies reported the role of IL-1β in neuroinflammation and neurodegeneration especially within the field of Alzheimer’s disease: for example, postmortem brain sample analysis revealed elevated levels of Il-1β production, including around amyloid beta plaques; all suggestive of pathology-associated inflammation (Cacabelos et al., 1994; Shaftel et al., 2008; Italiani et al., 2018).