Given emerging evidence indicating the influence of nerves within the tumor microenvironment on cancer progression,[68, 69] we first confirmed the protein level of nerve fibers marker (antineurofilament heavy,[70] NF) in breast cancer tissue (Figure S21d, Supporting Information), subsequently examined the neuroreceptor expression level in scRNA‐seq data and discovered that C1 specifically expressed adrenergic receptors (ARs) ADRB2 and ADRA2B (Figure 5e). This evidence concerns the gene ADRA2B and breast carcinoma.