The activated CD4 + T-cells then secrete interleukin-2 (IL-2), interleukin-12 (IL-12), interferon-gamma (IFN-γ) and activate CD8 + T-cells resulting in keratinocyte apoptosis which contributes to basal cell degeneration in OLP pathology [4]. This evidence concerns the gene IL2 and oral lichen planus.