This study supports the biological link between chronic stress, insulin resistance and C.I. CRS induced learning and memory impairment symptoms (decreased spontaneous alteration ratio in Y maze test and decreasing latency with increasing time spent in target quadrant in MWM test) in addition to neurodegenerative changes in CA1 of hippocampus with metabolic disturbances (increased glucose, cortisol, and HOMA-IR with decreased insulin secretion), impairing insulin signaling pathway. The gene discussed is INS; the disease is Insulin resistance.