Chronic restraint stress of Wistar male rats significantly decreased hippocampal ATP content (P < 0.0001) and decreased CCO enzyme in the brain (P < 0.01) as compared to control group, while DGF treatment in CRS-DGF-administered group significantly increased hippocampal ATP content (P < 0.0001) and increased CCO enzyme (P < 0.01) as compared to the CRS (Table 2). This evidence concerns the gene RYR1 and congenital rubella syndrome.