Chronic restraint stress of Wistar male rats significantly increased hippocampal p-Akt, hippocampal p-mTOR levels (P < 0.001) as compared to control group, while DGF treatment in CRS-DGF-administered group decreased hippocampal p-Akt level significantly (P < 0.01) and decreased hippocampal p-mTOR level significantly (P < 0.001) as compared to the CRS group (Fig. 3). The gene discussed is AKT1; the disease is congenital rubella syndrome.