RYR1 and Cognitive impairment: Dapagliflozin through its insulin sensitizing effect improves insulin signaling by enhancement of BDNF gene expression along with decreasing Akt and mTOR, its antioxidant actions via reducing MDA and increasing GSH, mitochondrial function improvement by increasing ATP synthesis and enhances CCO activity expression in hippocampus and has promising effects on ameliorating cognitive deficits and neurodegeneration.