Chronic restraint stress of Wistar male rats significantly increased amyloid beta, p-tau levels in the brain (P < 0.0001), decreased BDNF gene expression in the hippocampus (P < 0.0001) as compared to control group, while DGF treatment in CRS-DGF-administered group significantly decreased in amyloid beta and brain p-tau levels (P < 0.001), significantly increased BDNF gene expression (P < 0.0001) as compared to the CRS group (Fig. 4). This evidence concerns the gene BDNF and congenital rubella syndrome.