PNLIP and obesity due to melanocortin 4 receptor deficiency: Not only that, Cardozo-Muñoz et al. found that G. mangostana fruits target α-amylase, α-glucosidase, and pancreatic lipase, key enzymes in carbohydrate and lipid metabolism, making them potential treatments for type 2 diabetes and obesity (Hu et al. 2021; Cardozo-Muñoz et al. 2022).