Although these data suggest common mechanisms for the expression of AKR1B1 in both epithelial and stromal compartments, we also observed that the tumor AKR1B1 score was significantly lower in stage 3 tumors (p < 0.01, Figure S9B), whereas the stromal AKR1B1 score did not show any significant difference between the different stages (data not shown). The gene discussed is AKR1B1; the disease is neoplasm.