Evaluation of AKR1B1 expression along with previously defined consensus molecular subtypes (CMS) of CRC [16] showed that AKR1B1 expression was the highest in CMS4 type, followed by CMS1, CMS2, and CMS3 (Figure S1B, p < 0.01 for all comparisons) type tumors. Here, AKR1B1 is linked to colorectal carcinoma.