CTNNB1 and colorectal carcinoma: Interestingly, a high macrophage to epithelial cell ratio was shown to improve prognosis in CRC; the same study showed that direct in vitro cell–cell contact between HCT‐116 CRC cells and macrophages led to epithelial cell death, whereas the lack of direct contact (translated to tumors with low macrophage infiltration) led to enhanced cancer cell migration and nuclear beta catenin levels [30].