The largest study, involving 46092 ED patients with suspected acute coronary syndrome, reported that hs-cTnI rule-in thresholds of 64 ng/L and five-fold URL provided positive predictive values of 59% and 62% with specificities of 96% and 98%, respectively, for diagnosing type 1 myocardial infarction[8]. This evidence concerns the gene TNNI3 and acute coronary syndrome.