To investigate the role of HMGB2 in macrophages on tumor cell phagocytosis, we performed co-culture assays using the murine macrophage cell line RAW264.7 and four human female-specific tumor cell lines: MDA-MB-231 (breast cancer), HeLa (cervical cancer), SKOV3 (ovarian cancer), and Ishikawa (endometrial cancer). Here, HMGB2 is linked to neoplasm.