ANO1 and colorectal carcinoma: Inhibition of ANO1 can downregulate the expression of the membrane proteins frizzled protein 1 (FZD1) and β-catenin, increase the level of glycogen synthase kinase-3β (GSK3β), disrupt the Wnt/β-catenin signalling pathway, and reduce the proliferative capacity of CRC cells (54).