To this end, it should be noted that in the case of PALB2 or BRCA1 mutant cancers, the patients are mostly heterozygous mutation carriers and only tumor cells have further lost or mutated the WT allele and become functionally null; therefore, autophagy inhibition can be expected to be more toxic to tumor cells than normalcells, including neurons. The gene discussed is PALB2; the disease is cancer.