To tackle this knowledge gap, here we used a range of tools, including cultured myotubes, aged mice and human muscle biopsies from subjects of different ages, to obtain a comprehensive view of the molecular and physiological events that occur during muscle aging and that link BNIP3 to mitochondrial dysfunction, defective mitophagy, inflammation, and sarcopenia [1]. Here, BNIP3 is linked to sarcopenia.