To understand the relationship between STAT3 activation and autophagy in GBM cells, we used CRISPR-Cas9 knockout (KO) of STAT3 in GBM cells and found that STAT3-KO activates autophagy, as shown by SQSTM1/p62 degradation and CTSD (cathepsin D)-associated lysosomal activity [1]. Here, CTSD is linked to glioblastoma.