For the patients who were sensitive to chemotherapy, the protein levels of SOX6 and MAP4K4, as well as the level of autophagy are lower than those in patients who are not sensitive to cisplatin, which further demonstrates that the high level of SOX6-induced autophagy mediated by MAP4K4 may reduce the sensitivity of cervical cancer cells to platinum-based chemotherapy. The gene discussed is MAP4K4; the disease is cervical cancer.