Hyperphosphorylation and aggregation of microtubule-associated tau (MAPT/Tau) is one of the hallmark pathologies of AD and a defining feature of a group of neuronal disorders termed tauopathies, including progressive supranuclear palsy, corticobasal degeneration, and frontotemporal dementias (FTDs) [136]. The gene discussed is MAPT; the disease is Alzheimer disease.