TBK1 and amyotrophic lateral sclerosis: In fact, an elaborate study by Harding and colleagues that investigated the impact of 10 ALS/FTD-linked mutations in TBK1 on mitophagy revealed that mutations that abolish either TBK1 dimerisation or reduce its kinase activity did not have a profound impact on mitophagy, while TBK1 variants that impacted both had a stronger disruptive impact on mitophagy [136].