Mutations in the gene encoding KIF5A (kinesin 5A), a neuron-specific anterograde molecular motor protein, are causative for hereditary spastic paraplegia (HSP) [444], Charcot-Marie-Tooth disease type 2 (CMT2) [445] and ALS [446,447]. This evidence concerns the gene KIF5A and Charcot-Marie-Tooth disease type 2.