VCP mutations are linked to numerous NDs including the multisystem proteinopathy called inclusion body myopathy associated with Paget disease of bone (PDB) and FTD (IBMPDD) [147], Charcot Marie Tooth disease type 2 (CMT2) [148] and ALS/FTD [146,149,150]. Here, VCP is linked to amyotrophic lateral sclerosis.