Protein misfolding, resulting in pathological protein inclusions in glia and neurons, such as α-synuclein in PD, amyloid-β plaques and tau tangles in AD, huntingtin in HD, Tau, TDP-43 and FUS in FTD, and TDP-43, SOD1, and FUS in ALS, is considered a hallmark of neurodegenerative diseases (NDs), including ALS and FTD [28-31]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.