Recently, the mechanism behind the dysregulation of the cyclin F-p62 axis was uncovered as cyclin F-dependent ubiquitylation of p62 was found to regulate its ability to aggregate and form cytoplasmic foci and that expression of the ALS and FTD-lined S621G CCNF mutant causes aberrant ubiquitylation and increased aggregation of p62 [360]. Here, CCNF is linked to amyotrophic lateral sclerosis.