Moreover, a recent study unveiled a novel function for SigR1 in the regulation of autophagy as the molecular chaperone was found to interact with POM121 (an important nucleoporin linked to C9orf72 ALS/FTD [329]) and regulate TFEB nucleocytoplasmic transport [330]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.