Although not being a direct genetic cause of ALS or FTD, genetic variants in the gene encoding TMEM106B (transmembrane protein 106B), a membrane protein especially present in neuronal and glial cells on (endo)lysosomes positive for Rab7, Rab9 and LAMP1 [396-400] and interactor of PGRN, are identified as risk factors for GRN-FTD and C9orf72-FTD [401-405]. This evidence concerns the gene TMEM106B and amyotrophic lateral sclerosis.