CHMP2B and amyotrophic lateral sclerosis: In addition, a recent screen in mutant CHMP2B Drosophila models discovered TBK1 and dynein, two factors involved in early endosome trafficking as modifiers of mutant CHMP2B toxicity [373], adding another layer of evidence for the involvement of both endolysosomal and autophagy dysregulation in the pathology of CHMP2B-ALS/FTD.