Some studies have shown that IGF-1 can be involved in the RhoA/ROCK signaling pathway, activating cancer cells to promote cell scattering and invasion [29], and can also activate the up-regulation of P13K through the IGF-1/IGF-1R-PI3K/Akt pathway [30], which can indirectly affect the process of enamel cell polarization, and the specific mechanisms need to be further investigated. The gene discussed is IGF1; the disease is cancer.