PKD2 and autosomal dominant polycystic kidney disease: In zebrafish, exoc5 morphants phenocopied pc2 depletion, and the manipulation of Exoc5 in MDCK cells led to aberrant ciliary assembly and mechanosensation defects reminiscent of Autosomal dominant polycystic kidney disease (ADPKD) (Fogelgren et al., 2011).