It was found in recent studies that this lipid-soluble vitamin was involved in ferroptosis, a programmed cell death caused by iron-dependent phospholipid peroxidation (43) and the deficiency of its downstream, all-trans retinoic acid, was mediated by retinol dehydrogenase 10 reduction and promoted diabetic cardiomyopathy in male mice (44). The gene discussed is RDH10; the disease is diabetic cardiomyopathy.