suggested that the vaccinia virus utilizes the EGFR as an entry receptor to infect L cells, and antibodies against EGFR reduce viral infections.[41] Although limited studies have been conducted on cellular receptors for MPXV, data from VACV imply that diverse macropinocytosis pathways utilized by MPXV may also be influenced by changes in actin dynamics resulting from relevant activation. Here, EGFR is linked to viral infectious disease.