MAPT and Alzheimer disease: The utilization of this methodology facilitates the comprehensive examination of protein phosphorylation sites and their corresponding patterns, thereby playing a pivotal role in the elucidation of pathological conditions characterized by excessive phosphorylation events.[124, 125] The present investigation involved conducting in vivo experiments using porous nylon TiO2 nanoparticles to elucidate the crucial phosphorylation sites of tau protein in the context of AD progression.