The microtubule misregulation paradigm is consistent with research demonstrating the significant role that stringent regulation of microtubule dynamics plays in ensuring the health and survival of cells [Figure 6].[26, 50, 51, 52, 53] To create targeted therapeutics to address the underlying causes of AD and other neurodegenerative conditions, it is essential to understand the molecular mechanisms underlying tau mutations and the impact of these mutations on cellular function. The gene discussed is MAPT; the disease is Alzheimer disease.