This study aims to systematically elucidate the hepatoprotective effects and molecular mechanisms of Pac in a high-fat diet-induced murine MASLD model, focusing on validating the hypothesis that “Pac exerts therapeutic effects in MASLD by suppressing ferroptosis through PPARα upregulation.” The findings may provide a theoretical foundation for developing natural product-based therapies for MASLD. The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatotic liver disease.