Microbiota-depleted IL-10−/− mice could be stably infected with C. jejuni and developed an acute enterocolitis with bloody inflammatory diarrhea within 1 week post infection and showed symptoms typical for severe campylobacteriosis in immunocompromised human patients (Haag et al., 2012c; Heimesaat et al., 2014a; Heimesaat et al., 2017; Mousavi et al., 2020a). This evidence concerns the gene IL10 and infection.