There are several causes of hypoglycemia which include drug-induced (such as via the use of exogenous insulin), critical illness (including sepsis, hepatic dysfunction, and cardiac dysfunction), hormone deficiencies (adrenal insufficiency or hypothyroidism), or endogenous overproduction of insulin which is also known as pancreatogenic hyper-insulinemic hypoglycemia (PHH). The gene discussed is INS; the disease is Sepsis.