Elevated levels of interleukin-8 (IL-8), IL-6, and matrix metalloproteinase-2 (MMP-2) can contribute to inflammation and vascular wall damage, which are key features of VZV vasculopathy.14This case highlights the importance of monitoring thromboembolic events in varicella patients, regardless of preexisting risk factors. Here, MMP2 is linked to vascular disorder.