Given the unusual nucleotide sizes of GLP-1R in four different species (Fig.S4) (Barrett et al., 2024), the gene set enrichment analyses (Supplementary Figure S5) suggested that in addition to GLP-1R, RNA activities of SLC25A6 and NFkB1 were significantly altered in AD and PD alike (Figures 2b–g). Here, SLC25A6 is linked to Parkinson disease.