Notably, we observed significant increases in the RNA activities of SQSTM1, associated with NF-kB signaling (Zou et al., 2020), in the CN of AD and PD patients (Figure 4b), while those of FKBP5, ZBTB16, and CALCOCO2 were elevated in AD alone (Figures 4a–c). This evidence concerns the gene ZBTB16 and Alzheimer disease.