GLP1R and Alzheimer disease: By conducting whole transcriptome RNA-Seq of the CN forming part of the basal ganglia in AD and PD, our approach aims to identify critical gene alterations that impact mitochondrial function, ER stress, and endosomal activity along with changes associated with key risk genes for AD (Scheltens et al., 2021), providing new insights into the molecular mechanisms underlying these diseases and the therapeutic effects of GLP-1R agonists.