NF-κB plays a central role in both AD (Lukiw, 2022; Sun et al., 2022; Patel et al., 2024; Soelter et al., 2024) and PD (Li et al., 2012; Jafari et al., 2022), regulating inflammation, cell survival, and immune responses. This evidence concerns the gene NFKB1 and Alzheimer disease.