NFKB1 and Alzheimer disease: Notably, we observed significant increases in the RNA activities of SQSTM1, associated with NF-kB signaling (Zou et al., 2020), in the CN of AD and PD patients (Figure 4b), while those of FKBP5, ZBTB16, and CALCOCO2 were elevated in AD alone (Figures 4a–c).