A significant body of evidence suggests the dysregulation of this process contributes to motor neuron degeneration in ALS and beyond, as reviewed previously.48 For example, the key ALS risk gene C9orf72 is implicated to regulate autophagy-lysosome related biology that if disrupted contributes to toxic protein aggregation.49,50 This is notable given that the signal for BRAFi targets was strongest in our GSEApreranked analyses of differential expression RNAseq-based data from C9orf72 carrier iPSMNs. Here, C9orf72 is linked to amyotrophic lateral sclerosis.