NEK1 and amyotrophic lateral sclerosis: The gene encoding NIMA-related kinase 1 (NEK1) appeared as a gene of interest highlighted using both common variant and rare variant led approaches (Supplementary Fig. 8), which previous experimental work suggests may be therapeutically actionable.38 As outlined in the supplementary text, we found that NEK1 exists within gene-sets relevant to the polygenic signal for ALS and is linked to ALS relevant clinical endpoints upon scanning an association between genetically predicted NEK1 expression and the human clinical phenome (Supplementary Fig. 7 and Supplementary Table 4).