C9orf72 and amyotrophic lateral sclerosis: An unmet need remains to also consider the relationship of putative repurposing candidates to extra-motor quality of life related measures, such as mental health challenges and pain.66 Given their lack of strong convergence at the gene-level we do not directly integrate common and rare-variant ranks, although we do find top-ranked genes supported by both approaches that are known as important to ALS (e.g. NEK1, C9orf72, etc.).