For instance, SF3B1, a crucial constituent in the RNA splicing cascade, when mutated, disrupts normal splicing mechanisms, resulting in aberrant mRNA and protein synthesis, a phenomenon commonly observed in malignancies such as chronic lymphocytic leukemia (CLL) and myelodysplastic syndromes (MDS) (32). This evidence concerns the gene SF3B1 and B-cell chronic lymphocytic leukemia.