Elongation factor 1-alpha (eeEF1 α) is a protein that has also been found in exosomes secreted by Leishmania in early infections and identified as a crucial factor for immunosuppression and priming of host cells for Leishmania invasion (Silverman and Reiner, 2012; Timm et al., 2017), a fact that could suggest it may have a similar role in infections with N. fowleri. This evidence concerns the gene EEF1A1 and infection.