However, we observed three genes (n = 3) included in theAll of Us “Hereditary Disease Risk” report with variants at an allelefrequency≥0.10 in the All of Us African genetic ancestry population:CACNA1S (two gene variants [n = 2], malignant hyperthermiasusceptibility), SCN5A (one variant [n = 1], Brugada syndrome and long QTsyndrome 3), and TP53 (one variant [n = 1], Li-Fraumeni syndrome; seeTable 3 and Supplement Table 3). This evidence concerns the gene TP53 and hereditary disease.