Unsupervised clustering analysis identified distinct cell clusters, including various immune cell types, such as antigen presenting cells (CD45+, HLA-DR+), monocytes (CD11b+), CD4+ T cells (CD4+) and B cells (CD20+), stroma cells (collagen+), vascular cells (CD31+), and tumor cells, including proliferating tumor cells (Ki67+) and CD44+ tumor cells (CD44+) (Figure 3B). Here, CD4 is linked to neoplasm.