Protein interaction network analysis revealed that HSPH1 forms a complex with chaperone proteins such as HSPA8, BAG2, and DNAJB1, which may promote tumour progression by regulating stress response and cell survival (26).Although the expression of these proteins does not differ significantly between lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), the concordance in their prognostic value suggests that HSPH1 may regulate stress adaptation through dynamic changes in post-translational modifications (e.g., phosphorylation, acetylation) or subcellular localisation. The gene discussed is BAG2; the disease is neoplasm.