Interestingly, we found that mitophagy inhibition in MTFP1-overexpressing cells significantly decreased cell viability and increased apoptosis upon exposure to cisplatin in comparison to the control MTFP1-overexpressing cells, suggesting that MTFP1 may enhance survival by preventing cell death through mitophagy in oral cancer cells. This evidence concerns the gene MTFP1 and lip and oral cavity carcinoma.