SQSTM1 and B-cell chronic lymphocytic leukemia: Furthermore, CQ increased the level of SQSTM1 by 25% in the CLL cells from Patient # 1; however, this phenomenon was not observed in the CLL cells from Patient # 2, while VCX did not decrease the relative level of SQSTM1 in the presence of CQ in Patient #1 (Fig. 2A).