And five, melanoma metastasis to the gallbladder, which can be diagnosed based on the history of melanoma, histological morphology, and immunohistochemistry for calcium-binding protein (S-100) (+), melanoma antigen recognized by T-cells 1 (MART 1) (+), SRY-box transcription factor 10 (SOX 10) (+) and AE1/AE3 (-) [15]. The gene discussed is SOX10; the disease is melanoma.