B-type natriuretic peptide (BNP) has reduced specificity for heart failure with preserved ejection fraction (HFpEF), for example, in obesity, increased clearance of BNP and NT-proBNP via the natriuretic peptide clearance receptor (NPR-C), and enhanced degradation by neprilysin contribute to lower circulating levels. The gene discussed is NPPB; the disease is obesity disorder.