GLP1R and Decreased liver function: Pioglitazone [20], semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA) [21], tirzepatide, a dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist (GIP/GLP-1RA) [22], and tofogliflozin, a sodium-glucose cotransporter 2 inhibitor (SGLT2i) [23], have all been shown to improve liver function in participants with liver dysfunctions, including NAFLD, NASH (MASH), and hepatic fibrosis, as demonstrated in randomized controlled trials (RCTs).