The GRN controlling neural crest EMT has been intensively studied and includes many more transcription factors than the core cancer network (Hovland et al., 2020; Simões-Costa and Bronner, 2015); these include inhibition of Ncad by Snai1/2 and Lmo4, and EMT initiation by FoxD3 with Sox 9/10 and AP2 (Simões-Costa and Bronner, 2015; Rogers et al., 2012). Here, LMO4 is linked to cancer.