CD274 and proliferative diabetic retinopathy: In the central nervous system, PD‐L1 exhibits a typical upregulation in response to inflammatory stimuli, which will reduce neuroinflammation and mitigate disease severity.[34] Previous investigations have substantiated an augmented expression of PD‐L1 in inflamed retinas,[78] although retinal PD‐L1 level was reported to be diminished in the proliferative diabetic retinopathy.[79] Our retinal RNA‐seq, PCR, and WB analyses disclosed a noteworthy elevation of retinal PD‐L1 subsequent to the laser‐induced CNV (Figures 1A,B, and 7A).