Studies have shown that soluble PD‐1 can bind to PD‐L1, triggering downstream signaling cascades.[48] In neuroinflammatory conditions such as multiple sclerosis, PD‐L1 expressed on immune cells interacts with PD‐1 to transmit inhibitory signals, playing a crucial role in maintaining immune homeostasis and suppressing inflammation.[49] We hypothesized that exogenous PD‐1 protein, by binding to PD‐L1, might activate downstream PD‐L1 signaling and further inhibit CNV formation in the CNV mouse model. This evidence concerns the gene CD274 and multiple sclerosis.